| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8533704 | Journal of Pharmacological and Toxicological Methods | 2018 | 30 Pages |
Abstract
Discussion: Our study demonstrates a general pharmacology-guided approach to setting a product specification for a bispecific antibody whose homomultimer-related impurities could lead to undesired biological effects.
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Authors
Sharmila Rajan, Junichiro Sonoda, Timothy Tully, Ambrose J. Williams, Feng Yang, Frank Macchi, Terry Hudson, Mark Z. Chen, Shannon Liu, Nicole Valle, Kyra Cowan, Thomas Gelzleichter,