Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8533761 | Journal of Pharmacological and Toxicological Methods | 2018 | 11 Pages |
Abstract
We conclude that wide-field imaging provides reliable qualitative data on an inhibitory effect on thrombus formation, despite differences which can emerge from various approaches to image analysis. However, quantitative evaluation and comparison of the efficacy of inhibitors on the basis of total area occupied by thrombi obtained by wide-field microscopy should be made with caution. To obtain a reliable quantitative assessment of the effect of a tested compound on thrombus structure the use of confocal microscopy is inevitable.
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Authors
Tomasz Przygodzki, Nina Wolska, Marcin Talar, Dawid Polak, Magdalena Gapinska, Cezary Watala,