| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8533808 | Journal of Pharmacological and Toxicological Methods | 2018 | 10 Pages |
Abstract
This novel LBA approach is independent of protein purification. It is suitable for drug discovery as it is upscalable to high throughput compound screening. It works well for SLC transporters which are underrepresented targets due to their difficulties to study them. Moreover, this approach could make a significant contribution toward “deorphanization” of SLCs, revealing their transport substrates.
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Authors
Benjamin Clémençon, Benjamin P. Lüscher, Matthias A. Hediger,