| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8533934 | Journal of Pharmacological and Toxicological Methods | 2018 | 30 Pages |
Abstract
We demonstrated that administration of a single LPS dose of 2Â ng/kg to healthy volunteers results in significant inflammatory and endothelial responses, without inducing clinically relevant signs of kidney injury. These findings support the application of the human endotoxemia model in future clinical pharmacology studies.
Keywords
Least square meanEGFVCAMTNFαICAMLPSMDRDB2mGOPNAKISAANAGUMODTLRPAMPN-acetyl-β-d-glucosaminidaseacute kidney injuryOsteopontinmodification of diet in renal diseasepathogen-associated molecular patternEndotoxininterleukinBeta2-microglobulinThrombomodulintumor necrosis factor alphauromodulinToll-like receptorLSMserum amyloid ACytokinesepidermal growth factorconfidence intervalEndothelial activationneutrophil gelatinase-associated lipocalinlipopolysaccharideKidney injury molecule 1cell adhesion moleculesintercellular adhesion moleculevascular cell adhesion moleculeC-reactive proteinCRP
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Eveline P. van Poelgeest, Marlous R. Dillingh, Marieke de Kam, Karen E. Malone, Marleen Kemper, Erik S.G. Stroes, Jacobus Burggraaf, Matthijs Moerland,