Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8536360 | Pharmacological Research | 2018 | 59 Pages |
Keywords
DCASDSCMCCYP7A1mRNACyPTCAHLBIBDHSDHMGCRBATIBSGCAPPARαpKaCFTRVPSTUDCAHHbCDCAFXRVDRUDCALXRSREBPPXRTGR5FGF15FMTCYP27A1BACSGlcAFaSSIFBSHMKCSteroid and xenobiotic receptorTCDCASXROCTN1CYP7B1Hydrophilic/lipophilic balanceGDCATDCAGCDCAGUDCAI-BABPTLCAG protein-coupled bile acid receptor 1TβMCA3-hydroxy-3-methyl-glutaryl-coenzyme A reductase7α-hydroxy-4-cholesten-3-oneASDsfarnesoid X receptormessenger RNAAsbtLCAChenodeoxycholic acidDeoxycholic acidTaurodeoxycholic acidTauroursodeoxycholic acidtaurochenodeoxycholic acidTaurolithocholic acidTaurocholic acidLithocholic acidCholic acidGlycodeoxycholic acidGlycoursodeoxycholic acidGlycochenodeoxycholic acidglycolithocholic acidglycocholic acidOstUrsodeoxycholic acidapical sodium-dependent bile acid transporteroxysterol 7α-hydroxylaseInflammatory bowel diseasetriglycerideHydrophilic/hydrophobic balancePharmacokinetic variabilityDrug absorptionfasted state simulated intestinal fluidDissociation constantPoorly water-soluble drugorganic solute transporterBCscystic fibrosis transmembrane conductance regulatorsodium dodecyl sulfateirritable bowel syndromeCytochrome P450biopharmaceutics classification systemfibroblast growth factor 15critical micelle concentrationLipid-based formulationsBile acid metabolismDrug metabolismGut microbiotaMicrobiomewild-typeBile salt hydrolasehydroxysteroid dehydrogenasepeptide transporter 1peroxisome proliferator-activated receptor-αAmorphous solid dispersionsSterol regulatory element-binding proteinfecal microbiota transplantationcholesterol 7α-hydroxylaseVitamin D receptorPregnane X receptor
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Authors
Elaine F. Enright, Brendan T. Griffin, Cormac G.M. Gahan, Susan A. Joyce,