Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Article ID	Journal	Published Year	Pages	File Type
8536432	Pharmacological Research	2018	14 Pages	PDF

Keywords

APD chronic atrioventricular block FDA Dehydroevodiamine hiPSC-CM CAVB CIPA IKr BVR EAD TDP VSD PMT HERG TCM STV HEK DMSO Comprehensive in vitro Proarrhythmia Assay early afterdepolarization right ventricle left ventricle Beat-to-beat variability of repolarization Short-term variability Molecular dynamics Dimethylsulfoxide LED Food and Drug Administration Human induced pluripotent stem cell-derived cardiomyocytes Ectopic beats traditional Chinese medicine Photomultiplier Action potential duration map wild type DHE Monophasic action potentials human Ether-a-go-go Related Gene human embryonic kidney

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Authors

Igor Baburin, Rosanne Varkevisser, Anja Schramm, Priyanka Saxena, Stanislav Beyl, Phillip Szkokan, Tobias Linder, Anna Stary-Weinzinger, Marcel A.G. van der Heyden, Marien Houtman, Hiroki Takanari, Malin Jonsson, Jet H.D. Beekman, Matthias Hamburger,