Article ID Journal Published Year Pages File Type
8536524 Pharmacological Research 2018 12 Pages PDF
Abstract
In conclusion, natural products from plants represent interesting candidates for AD treatment. They may qualify as promising compounds for the development of derivatives providing enhanced pharmacological features.
Keywords
iNOSNrf2NADPHBACE1AβN-methyl-d-aspartic acidIKKPKCPS1Bcl-2GSK-3NMDAPGE2intracerebroventricularICVcox2APPNeuNIκBIL-1βMMPInterferoneNucleotide-binding oligomerization domain-like receptorNALP3LPSIL-6SIRT-1JnkNSAIDNCoRRACNF-κBTRAFAP1CDC42GFAPRAGENFAT1c-Jun N-terminal kinaseERK1/2MAPKpresenilin 1ROSSTATneuronal nuclear antigenAChEcognitive impairmentmild cognitive impairmentacetylcholine esteraseIFNinterleukin 1βinterleukin 6Baxamyloid betaAlzheimer’s diseaseNeurodegenerative diseasestumor necrosis factor αCNSSODBBBSuperoxide dismutasecentral nervous systemcyclooxygenase 2Nuclear Factor of Activated T CellsTNF receptor associated factorNon-steroidal anti-inflammatory drugTNF-αnuclear factor (erythroid-derived 2)-like 2Natural productsB-cell lymphoma 2lipopolysaccharidematrix metalloproteinaseBlood-brain barrierinhibitor of nuclear factor kappa-B kinaseSmall molecule inhibitorNitric oxideMCIHistone acetyltransferaseRAS-related C3 botulinum toxin substrateBcl-2-associated X proteinGlial fibrillary acidic proteinactivator protein 1amyloid precursor proteincell division control protein 42 homologProtein kinase Cmitogen-activated protein kinaseProstaglandin E2reduced nicotinamide adenine dinucleotide phosphateHATextracellular signal-regulated kinase 1/2glycogen synthase kinase 3Reactive oxygen speciesBotanicalsMedicinal plantsReceptor for advanced glycation end productsnuclear receptor co-repressor
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Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
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