Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches

Article ID	Journal	Published Year	Pages	File Type
8536558	Pharmacological Research	2018	48 Pages	PDF

Keywords

Polypharmacology Drug-target interaction LPAR MOA FPR EP4 GPCR DTI EC50 NBI ROC IC50 ADE AUC Recall Dissociation constant Precision TPR Computational approach Adverse drug event half-maximal effective concentration Systems pharmacology area under the receiver operating characteristic curve inhibition constant Mechanism of action False positive rate True positive rate half-maximal inhibitory concentration lysophosphatidic acid receptor receiver operating characteristic G protein-coupled receptor

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches

Authors

Zengrui Wu, Weiqiang Lu, Weiwei Yu, Tianduanyi Wang, Weihua Li, Guixia Liu, Hankun Zhang, Xiufeng Pang, Jin Huang, Mingyao Liu, Feixiong Cheng, Yun Tang,