Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4

Article ID	Journal	Published Year	Pages	File Type
8536582	Pharmacological Research	2018	13 Pages	PDF

Keywords

MC3T3-E1 T2DM OPN OPG Oct4 OCN GLUT osterix BMP2 mTORC TSC RANKL FOXO1 RUNX2 LKB1 SIRT6 FCM AMPK NF-κB AMP-activated protein kinase NAD+ALP Alkaline phosphatase Akt Osteoprotegerin Osteopontin Osteocalcin Osx tuberous sclerosis glucose transporters Type 2 diabetes mellitus runt related transcription factor 2 high glucose concentration octamer-binding transcription factor 4 nuclear factor kappa-light-chain-enhancer of activated B cells Metformin knockout nicotinamide adenine dinucleotide Mammalian target of rapamycin complex Forkhead box protein O1 bone morphogenetic protein 2 protein kinase B liver kinase B1 receptor activator of nuclear factor kappa-B ligand

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Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4

Authors

Wei Mu, Zhuoran Wang, Chuanyu Ma, Yunyun Jiang, Nannan Zhang, Kaiqiang Hu, Liyuan Li, Zhao Wang,