Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Article ID	Journal	Published Year	Pages	File Type
8536636	Pharmacological Research	2018	20 Pages	PDF

Keywords

EGFR PI3K CDK MMP PTM nES MST TSA tPA EGCG mTOR ERK HDAC NRF 12-O-tetradecanoylphorbol-13-acetate SFN Hsp pKa SIRT sirtuin GBM HDACi FADD Bcl TGF NLS HIF hsf Dnmt VCP SAHA GSK FLIP CLL VEGFR UDCA TSG HDAC6 CTCL IIP DMB PRX Trichostatin A (PubChem CID: 444732)Sulforaphane (PubChem CID: 5350)Genistein (PubChem CID: 5280961)RhoB SMRT TPPP HDAC6 inhibitor Runx FDA ZBG FLICE inhibitory protein AML SRSF (−)-Epigallocatechin-3-gallate (PubChem CID: 65064)Janus kinase (−)-Epigallocatechin-3-gallate DNA methyltransferase HCC MAPK STAT Ellagic Acid (PubChem CID: 5281855)Ursolic acid (PubChem CID: 64945)Ursolic acid Suberoylanilide hydroxamic acid post-translational modification Ellagic acid Ursodeoxycholic acid interleukin Bax transforming growth factor Natural compounds Trichostatin A EMT Ubiquitin-binding domain Tau ICD Microtubule Food and Drug Administration Cancer therapy Endothelial cell Sulforaphane Cyld Cylindromatosis nuclear export signal nuclear localization signal HMGN runt-related transcription factor nuclear factor erythroid 2-related factor Hypoxia-inducible factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Heat shock transcription factor phosphatase and tensin homolog phosphoinositide 3-kinase FLICE B-cell lymphoma Cutaneous T-cell lymphoma acute myeloid leukemia Acute lymphoblastic leukemia Chronic lymphocytic leukemia matrix metalloproteinase HDAC inhibitor Signal transducer and activator of transcription Immunogenic cell death Multiple myeloma Cancer hallmarks mammalian target of rapamycin ALL Histone acetyltransferase histone deacetylase Bcl-2-associated X protein Valosin-containing protein Heat shock protein Protein phosphatase activator protein Cytoplasmic linker protein Fas-associated protein with death domain protein kinase A mitogen-activated protein kinase Peroxiredoxin JAK Pten Tumor suppressor gene Hepatocellular carcinoma HAT Clip Curcumin (PubChem CID: 969516)extracellular signal-regulated kinase cyclin-dependent kinase epithelial-to-mesenchymal transition Zinc binding group Glioblastoma glycogen synthase kinase VEGF receptor Androgen Receptor Estrogen receptor Epidermal growth factor receptor glucocorticoid receptor

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Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Authors

Manon Lernoux, Michael Schnekenburger, Mario Dicato, Marc Diederich,