Globular adiponectin protects hepatocytes from tunicamycin-induced cell death via modulation of the inflammasome and heme oxygenase-1 induction

Article ID	Journal	Published Year	Pages	File Type
8536722	Pharmacological Research	2018	45 Pages	PDF

Keywords

DAMPs NLRP3 TUN TUDCA Heme oxygenase-1 ATF6 tunicamycin UPR IL-1β HBSS PAMPs HO-1 NAC TCA ASC C/EBP homologous protein Hepatocytes IRE1α MDMs N-acetylcysteine ROS SnPP TNF- α adiponectin globular adiponectin ER stress Tauroursodeoxycholic acid inflammasomes damage-associated molecular patterns pathogen-associated molecular patterns NADPH oxidase interleukin 1β CHOP Tumor Necrosis Factor- α activating transcription factor 6 lactate dehydrogenase LDH monocyte-derived macrophages Hank’s balanced salt solution nicotinamide adenine dinucleotide phosphate-oxidase Unfolded protein response apoptosis-associated speck-like protein containing a CARD protein kinase RNA-like endoplasmic reticulum kinase tin protoporphyrin IX PERK Reactive oxygen species

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Globular adiponectin protects hepatocytes from tunicamycin-induced cell death via modulation of the inflammasome and heme oxygenase-1 induction

Authors

Amrita Khakurel, Pil-Hoon Park,