Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8536780 | Pharmacology & Therapeutics | 2018 | 62 Pages |
Abstract
Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.
Keywords
ECMILVsARF6EVSPLD2ESCRTMDSCISGMVBPMNnSMase2Neutral sphingomyelinase 2RBPPRRMSCDAMPADP ribosylation factor 6gDNASNAREMitochondrial DNAgenomic DNAintraluminal vesiclesdanger-associated molecular patternsmultivesicular bodyExtracellular vesiclesmtDNAMesenchymal stem cellmyeloid-derived suppressor cellMIFPre-metastatic nicheMacrophage inhibitory factorPhospholipase D2Extracellular matrixendosomal sorting complex required for transportMultiple myelomaTumor microenvironmentRNA-binding proteininterferon-stimulated genepattern recognition receptor
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Authors
Maarten P. Bebelman, Martine J. Smit, D. Michiel Pegtel, S. Rubina Baglio,