| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8536965 | Pharmacology & Therapeutics | 2018 | 47 Pages |
Abstract
The protein disulfide isomerase (PDI) gene family is a protein family classically characterized by endoplasmic reticulum (ER) localization and isomerase and redox activity. ERp57, a prominent multifunctional member of the PDI family, is detected at various levels in multiple cellular localizations outside of the ER. ERp57 has been functionally linked to a host of physiological processes and numerous studies have demonstrated altered expression and aberrant functionality of ERp57 in association with diverse pathological states. Here, we summarize available knowledge of ERp57's functions in subcellular compartments and the roles of dysregulated ERp57 in various diseases toward an emphasis on the potential utility of therapeutic development of ERp57.
Keywords
PLCBMP-2NCCMCUTNFR2TNFR1PDIA3AP-1mTORC1ECMADAM10HDMUPRPKCSTIM1TrxPLA2CrtTGF-βPDIEGFRSTAT3Nuclear vitamin D receptorNF-κBEGFERp57TNFαp53a disintegrin and metalloproteinase 10mTORGFAP1α,25(OH)2D31,25-dihydroxyvitamin D3atRAMAPK/ERKmTOR complex 1mitochondrial outer membrane permeabilizationall-trans retinoic acidphospholipase A2AIFClinical biomarkerTransforming growth factor βNeurodegenerationtumor necrosis factor αthioredoxinCancerTumor suppressor p53Musculoskeletal systemendoplasmic reticulumapoptosis-inducing factorepidermal growth factornuclear factor kappa betaExtracellular matrixMOMPsignal transducer and activator of transcription 3Mitochondrial calcium uniporterpeptide loading complexmajor histocompatibility complexMHCMechanistic target of rapamycinUnfolded protein responseImmune responseGlial fibrillary acidic proteinprotein disulfide isomeraseactivator protein 1bone morphogenic protein 2Protein kinase Ccalreticulinsodium-chloride cotransportercalnexinHouse dust miteRetinoic acid receptorEpidermal growth factor receptortumor necrosis factor receptor 1tumor necrosis factor receptor 2
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Authors
Aubryanna Hettinghouse, Ronghan Liu, Chuan-ju Liu,