| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8537029 | Pharmacology & Therapeutics | 2017 | 15 Pages |
Abstract
In this review, we will describe the physiological functions of GPNMB in normal tissues and summarize the processes through which GPNMB augments tumor growth and metastasis. We will review the pre-clinical and clinical development of glembatumumab vedotin, evaluate on-going clinical trials, explore emerging opportunities for this agent in new disease indications and discuss exciting possibilities for this ADC in the context of combination therapies.
Keywords
M-CSFVEGFR2HNSCCERKMDSCRTKIL-1βIL-10TFENRP1BRKIFN-γMITFTCGAα-MSHASPSGM-CSFEGFRMTDHB-EGFPKDmonomethyl auristatin Emacrophage-colony-stimulating factorMDASTNBCPMEL17MMAELPSGPNMBHIF1αPBMCIRAESCCORRADCECDBMP-2breast tumor kinaseBrentuximab vedotinMAPKPFsThe cancer genome atlasIHCImmunohistochemistryInterleukin-10interleukin-1betaProgression free survivaloverall survivalpolycystic kidney diseasetumor necrosis factor alphaMaximum tolerated doseextracellular domainDORalveolar soft part sarcomaCancer therapyTriple negative breast cancerPeripheral blood mononuclear cellmyeloid derived suppressor cellextracellular signal regulated kinaseadverse eventhypoxia inducible factor 1 alphagranulocyte macrophage-colony-stimulating factorimmune-related adverse eventgranulocyte-colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Microphthalmia-associated transcription factorG-CSFTNF-αLAMPlipopolysaccharideduration of responseobjective response rateneuropilin-1alpha-melanocyte stimulating hormonelysosomal-associated membrane proteinBone morphogenetic protein-2mitogen-activated protein kinaseSquamous cell carcinomaHead and neck squamous cell carcinomaAntibody-drug conjugateInterferon gammaReceptor Tyrosine Kinasevascular endothelial growth factor receptor 2Epidermal growth factor receptor
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Authors
April A.N. Rose, Marco Biondini, Rafael Curiel, Peter M. Siegel,