| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8541949 | Journal of Pharmacy Research | 2013 | 6 Pages |
Abstract
A dose dependent cerebroprotective action of pyrimidines (AUCP1 and AUCP2) in terms of limiting the infarct size was observed in the present in vivo model of cerebral I/R in Wistar rats. The antioxidant role of pyrimidines (AUCP1 and AUCP2) in cerebroprotection was confirmed by measuring SOD, CAT, MDA, levels. MDA levels were decreased; SOD and CAT levels were increased by treatment with pyrimidines (AUCP1 and AUCP2). The cerebroprotective actions of pyrimidines (AUCP1 and AUCP2) are partially attributed to their anti-inflammatory effects against I/R injury in rats as evidenced by significant reduction in pro-inflammatory markers MPO, TNF-α and significant increase in anti-inflammatory marker IL-10. Pyrimidines (AUCP1 and AUCP2) evaluated in the present investigation has offered significant cerebroprotection against ischemia-reperfusion induced cerebral infarction in rats.
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Authors
Venkata Satyanarayana Murthy Bendi, Akula Annapurna, Vasudeva Rao Avupati,