Stability-indicating HPTLC method for simultaneous determination of Ketoprofen, Methyl Paraben and Propyl Paraben in gel formulation

A low relative standard deviation (<2%) was found for both precision and robustness study showing that the proposed method was precise and robust. The method had an accuracy of 99.95%, 99.85% and 100.07 of Ketoprofen, Methyl Paraben, Propyl Paraben respectively were validated according to ICH guidelines. The drug showed instability in oxide, heat and UV light, while it remained stable in neutral conditions.