Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

Article ID	Journal	Published Year	Pages	File Type
8620551	Journal of Critical Care	2018	9 Pages	PDF

Abstract

The results point to HS as a main driver for glycocalyx and barrier breakdown and suggest novel tools for the monitoring of organ dysfunction in the early course after PT.

Keywords

MODS TASH NGAL Polytrauma PCT L-FABP MMP-13 I-FABP GCs S1P AIS ISS CC16 RBC liver-type fatty acid binding protein DAMP APTT AKI ROTEM acute kidney injury Sequential Organ Failure Assessment Sphingosine-1-phosphate Rotational thromboelastometry activated partial thromboplastin time Multiple organ dysfunction syndrome Systemic inflammatory response syndrome Hemorrhagic shock Multiple organ failure neutrophil gelatinase-associated lipocalin Matrix metalloproteinase 13 Abbreviated Injury Scale Glasgow coma scale Injury severity score Clara cell protein 16 Procalcitonin multiple trauma SOFA red blood cell Glycocalyx

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Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma

Authors

Rebecca Halbgebauer, Christian K. Braun, Stephanie Denk, Benjamin Mayer, Paolo Cinelli, Peter Radermacher, Guido A. Wanner, Hans-Peter Simmen, Florian Gebhard, Daniel Rittirsch, Markus Huber-Lang,