Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease

Article ID	Journal	Published Year	Pages	File Type
8624073	Experimental and Molecular Pathology	2018	5 Pages	PDF

Abstract

Results herein suggest that in addition to severe dysregulation of anti-oxidant responses, cholestasis impacts both cytosolic/nuclear (Trx1) as well as mitochondrial (Trx2) redox signaling and control pathways.

Keywords

IBD UDCA Trx GCLC TXNIP BDL TrxR Cholangiocyte ALT PSC thioredoxins LTX HO-1 Gamma-glutamylcysteine GST GSH Prdx 4-HNE PBC 4-hydroxy-2-nonenal primary biliary cholangitis ROS Alanine aminotransferase Ursodeoxycholic acid Inflammatory bowel disease thioredoxin reductase Oxidative stress thioredoxin heme oxygenase 1 Thioredoxin interacting protein Peroxiredoxin bile duct ligation Liver transplant reduced glutathione Primary sclerosing cholangitis cholestasis glutathione S-transferase Reactive oxidative species