Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease

Article ID	Journal	Published Year	Pages	File Type
8624179	Experimental and Molecular Pathology	2018	30 Pages	PDF

Abstract

Results herein provide additional evidence that cholestasis induces significant increases in periportal oxidative stress and suggest that there are significant differences in the cellular and subcellular generation of reactive aldehydes formed during cholestatic liver injury. Furthermore, these data suggest that anti-oxidant responses are dysregulated during end-stage PSC/IBD supporting pathological data. This work was funded by NIH5R37AA009300-22 D.R.P.

Keywords

PBS NAFLD MDA WCE αSMA CYP2E1 Cholangiocyte LTX INR SOD2 ALT IBD PSC HO-1 4-HNE GPX GST PSR Aldehyde 4-hydroxy-2-nonenal primary biliary cholangitis MPO ROS ALD AST Aspartate aminotransferase Alanine aminotransferase alpha smooth muscle actin nonalcoholic steatohepatitis alcoholic liver disease Nonalcoholic fatty liver disease Inflammatory bowel disease Oxidative stress Mitochondrial superoxide dismutase cytochrome P4502E1 malondialdehyde Model for End-Stage Liver Disease myeloperoxidase International Normalized Ratio Nash heme oxygenase 1 Lipid peroxidation Liver transplant Primary sclerosing cholangitis cholestasis MELD glutathione S-transferase glutathione peroxidase Reactive oxidative species