Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Î6- desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial

Article ID	Journal	Published Year	Pages	File Type
8624601	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)	2018	33 Pages	PDF

Abstract

Prednisolone dose-dependently increases DNLi and SCDi and decreases D6Di in plasma CE, PL and TG in healthy males after 2 weeks. The observed unfavorable effects on fatty acid metabolism were related to the induction of glucocorticoid-induced insulin resistance.

Keywords

NEFA EPA CTG FPG OGTT PPR HOMA-IR FPI Oral glucose tolerance test Eicosapentaenoic acid docosahexaenoic acid Fatty acids non-esterified fatty acids fasting plasma insulin Triglycerides Insulin sensitivity DHA body mass index BMI Phospholipids Fasting plasma glucose Prednisolone cholesteryl esters Glucose Glucocorticoid

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Clinical Biochemistry

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Influence of prednisolone on parameters of de novo lipogenesis and indices for stearoyl-CoA- and Î6- desaturase activity in healthy males: A Post-hoc analysis of a randomized, placebo-controlled, double-blind trial

Authors

I.G. Pranger, D.H. van Raalte, M. Brands, M.H.A. Muskiet, I.P. Kema, M.J. Serlie, M. Diamant, S.J.L. Bakker, F.A.J. Muskiet,