Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8651227 | The American Journal of Cardiology | 2018 | 31 Pages |
Abstract
We aimed to characterize of the role of insulin-like growth factor-binding protein 7 (IGFBP-7) in heart failure (HF) pathophysiology. IGFBP-7 has been associated with cardiac hypertrophy and diastolic dysfunction in HF. In 86 patients with HF with a preserved ejection fraction (HFpEF) (ejection fraction [EF] â¥45%) and 79 with HF with a reduced ejection fraction (HFrEF), we assessed concentrations of serum IGFBP-7, correlations between serum IGFBP-7 and clinical data, diastolic function, and associations with outcome. IGFBP-7 was lower in HFpEF than HFrEF (102 vs 152 µg/L, p <0.001) and correlated with New York Heart Association class (HFpEF: râ=â0.25, pâ=â0.020; HFrEF: r = 0.26, pâ=â0.022), N-terminal pro-brain natriuretic peptide (NT-proBNP) (HFpEF: râ=â0.53, p <0.001; HFrEF: râ=â0.50, p <0.001), and estimated glomerular filtration rate (eGFR) (HFpEF: râ=ââ0.47, p <0.001; HFrEF: râ=ââ0.45, p <0.001). In HFpEF, IGFBP-7 correlated with E/eâ² (râ=â0.31, pâ=â0.012) and E/A ratio (râ=â0.31, pâ=â0.011). In HFrEF, but not HFpEF, IGFBP-7 correlated with age (râ=â0.29, pâ=â0.009) and atrial fibrillation (râ=â0.34, pâ=â0.002). IGFBP-7 predicted the outcome in HFpEF (hazard ratio 4.19 [1.01 to 17.35], pâ=â0.048]) but not in HFrEF (0.72 [0.24 to 2.14], pâ=â0.554). In conclusion in HFrEF, IGFBP-7 was elevated and associated with HF severity but not prognostic, suggesting a marker of risk. In HFpEF, IGFBP-7 was less elevated but associated with markers of diastolic dysfunction, HF severity, and prognosis. IGFBP-7 may contribute to the progression of HFpEF possibly through inflammation and oxidative stress.
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Authors
Camilla RN, PhD, Mette MD, PhD, Jan MD, PhD, Harvest F. MD, PhD, Kerstin MD, PhD, Erwan MD, PhD, Jean-Claude MD, PhD, Cecilia MD, PhD, Lars H. MD, PhD,