Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8651620 | The American Journal of Cardiology | 2017 | 8 Pages |
Abstract
Recent trends in use of antihypertensive drugs are unknown. From Danish nationwide prescription data, we obtained information on primary care use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers, diuretics, aldosterone receptor antagonists, and calcium channel blockers. During 1999 to 2015, the use of antihypertensive drugs per 1,000 inhabitants/day increased from 184 to 379 defined daily doses (DDD), corresponding to a rise in the prevalence proportion of users from â20% to â35%. From 1999 to 2015, a notable increase was observed for angiotensin-converting enzyme inhibitors (from 29 to 105 DDD per 1,000 inhabitants/day â260%) and angiotensin II receptor blockers (from 13 to 73 DDD per 1,000 inhabitants/day â520%). For diuretics the use remained stable, with a slight decrease (from 89 to 81 DDD per 1,000 inhabitants/day ââ10%). The use of aldosterone receptor antagonists increased until 2007 and remained unchanged at around 3.5 DDD per 1,000 inhabitants/day thereafter (average change â65%). The use of beta blockers doubled during the study period (from 17 to 34 DDD per 1,000 inhabitants/day â100%), entirely driven by increasing use of metoprolol. Similar trends were observed for calcium channel blockers (from 34 to 82 DDD per 1,000 inhabitants/day â140%), where amlodipine drove the overall increase. In conclusion, antihypertensive drug use has increased remarkably during the past 2 decades.
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Authors
Jens MD, PhD, Kasper MD, PhD, Kathryn E. PhD, Laurie A. PhD, Morten PhD,