Ldlr−/− and ApoE−/− mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease

The human cIMT signature was partially mimicked by Ldlr−/− and ApoE−/− mice. These animal models might help better understand the biochemical and molecular mechanisms involved in the vessel metabolic perturbations associated with, and contributing to metabolic disorders in CVD.