Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8658926 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews | 2017 | 22 Pages |
Abstract
Polycystic ovarian syndrome (PCOS) is associated with multiple cardiovascular risk factors (CVRF) including endothelial dysfunction (ED) and presence of metabolic syndrome (MS). The probable reason suggested for elevated CVRF in PCOS is oxidative stress (OS), which is an integral factor in cardiometabolic complications (CMC) seen in PCOS women. The interrelated mechanisms by which CVRF instigate clinical manifestation plays a crucial role in identification of a strategy to treat different comorbidities in PCOS. The existing treatment for PCOS mostly focuses on management of individual disorders, however, therapeutic strategies or novel targets to address cardiovascular complications in PCOS deserve extensive analysis.
Keywords
pTHTGFβvWFeNOShs-CRPRAASCBST2DICAM1HcyMNCRAGEVSMCPAI-1DDAHAT1RPCOSPRMTMTHFRVDRNFkBsirtuin1PEMTCVRFHHcySirtuin-1NMMAVCAM1Et1von Willibrand factorSirt1CMCTNFαCVSADMAMMPtPANOxROSangiotensin-IIAngiotensin converting enzyme inhibitorEndothelial dysfunctionendothelin-1NADPH oxidaseinterleukinscardiovascular diseasetransforming growth factor-βOxidative stresstumor necrosis factor-alphaAng-IIasymmetric dimethylarginineDiabetes mellitusCVDVascular smooth muscle cellsEndothelial cellsMononuclear cellsAgeendothelial nitric oxide synthaseCardiometabolic syndromepolycystic ovarian syndromeMetabolic syndromecystathionine beta synthaseRenin Angiotensin Aldosterone SystemCardiovascular systemCardiovascular risk factorsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Nuclear factor-kBtissue plasminogen activatorlow density lipoproteinLDLmatrix metalloproteinaseMethylenetetrahydrofolate reductaseAdvanced glycation end productsInsulin resistanceACEI یا angiotensin convert enzyme inhibitorAdhesion moleculesNitric oxideparathyroid hormonehomocysteineHyperhomocysteinemiaHypovitaminosis Dprotein arginine methyltransferaseC-reactive proteinCRPReactive oxygen speciesVitamin D receptor
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Authors
B.S. Nayaker, Sowmya Thomas, Sandhiya Ramachandran, Swetha Loganathan, Meenakshi Sundari, Kanchana Mala,