| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8658944 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews | 2017 | 5 Pages |
Abstract
Type 2 diabetes mellitus is a common type of diabetes and considered as multifactorial disease. Apelin is an adipokine which secreted from white adipose tissue and involved in various functions such as insulin sensitivity and food intake. Many studies showed that apelin has a crucial role in diabetes and its concentration will change in relation with insulin resistance. In this review, we will discuss the roles of apelin in energy metabolism and pathogenesis of diabetes and explain why apelin can be a good candidate adipokine to promoting insulin sensitivity.
Keywords
AMPKPLCβeNOSGPCRsBATRPEAT1PAI-1GDMT2DMPDRAPJRBP-4Endothelial NO-synthaseIRE1αinositol-requiring enzyme 1αretinal pigment epitheliumWhite adipose tissuebrown adipose tissuecardiovascular diseaseApelinGestational diabetes mellitusDiabetes mellitusType 2 diabetes mellitusdiacylglyceroldiabetic retinopathyProliferative diabetic retinopathyCVDDAGWorld Health Organizationbody mass indexBMIVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)ObesityInsulin resistanceDiabetic nephropathyretinol binding proteinWATWHOAngiotensin II receptor
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Authors
Farzaneh Ghafarian Alipour, Mohamad Reza Ashoori, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami,