Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice

Article ID	Journal	Published Year	Pages	File Type
8661993	International Journal of Cardiology	2018	29 Pages	PDF

Abstract

Dietary supplementation of strawberry attenuates indices of vascular inflammation and dysfunction in diabetic db/db mice. The effect of strawberry on vasculature is endothelial-dependent and possibly mediated through their circulating metabolites. Strawberry might complement conventional therapies to improve vascular complications in diabetics.

Keywords

IL-8 eNOS DAF DCFDA ICAM-1 PAL MAECs mouse aortic endothelial cells VCAM-1 MCP1 2′,7′-dichlorofluorescein diacetate 4-Amino-5-Methylamino-2′,7′-Difluorofluorescein Diacetate BSA l-NAME l-NG-Nitroarginine methyl ester NADPH oxidases NFκB NOx ROS bovine serum albumin Endothelial dysfunction Vascular inflammation Interleukin-8 Diabetes Strawberry tumor necrosis factor-α db/db endothelial nitric oxide synthase TNF-α nuclear factor κB Metabolites Diabetic mice intercellular adhesion molecule-1 vascular cell adhesion molecule-1 Nitric oxide monocyte chemoattractant protein-1 Reactive oxygen species

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice

Authors

Chrissa Petersen, Divya Bharat, Brett Ronald Cutler, Samira Gholami, Christopher Denetso, Jennifer Ellen Mueller, Jae Min Cho, Ji-Seok Kim, J. David Symons, Pon Velayutham Anandh Babu,