Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8665779 | Journal of the American College of Cardiology | 2018 | 20 Pages |
Abstract
We demonstrated that the presence of GATA3-positive macrophages adversely affects remodeling of the myocardium in response to ischemia or pressure overload, whereas the absence of these macrophages led to a significant improvement in cardiac function. Targeting of signaling pathways that lead to the expression of GATA3 in macrophages may have favorable cardiac outcomes.
Keywords
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Authors
Mingjie PhD, Lei MD, Lai MD, Ada MS, Haley MS, Fuqiang PhD, Minghui PhD, Homayon PhD, Behrooz G. PhD, Prediman K. MD,