Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8668964 | Journal of Electrocardiology | 2018 | 16 Pages |
Abstract
A 26-year-old woman, 12 days in postpartum, developed recurrent syncope and cardiac arrest. Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). She also had intermittent LBBB (80Â bpm) on alternate beats and RBBB at sinus tachycardia (113Â bpm). Family genotyping revealed a novel de novo missense mutation G604C of KCNH2. Propranolol slowed heart rate and further prolonged QT interval (610Â ms) that caused TdP recurrence. Mexiletine combined with magnesium and potassium supplements prevented TdP/VF recurrence. This patient has remained event-free after 9-month follow-up.
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Authors
Chunlin MD, PhD, Ping MD, PhD, Jing MD, PhD, Li MD,