Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8679781 | Trends in Cardiovascular Medicine | 2018 | 10 Pages |
Abstract
Even small changes (~1Â mM) in [K+]o result in significant alterations in two different K+ currents, IK1 and HERG. These changes can markedly alter in resting membrane potential and/or action potential waveform in human ventricle. Specifically, a reduction in net outward transmembrane K+ currents (repolarization reserve) and an increased substrate input resistance contribute to electrophysiological instability during the plateau of the action potential and may promote pro-arrhythmic early after-depolarizations (EADs). Translational settings where these insights apply include: optimal diuretic therapy, and the interpretation of data from Phase II and III trials for anti-arrhythmic drug candidates.
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Authors
Beatriz PhD, Karen PhD, Lucia PhD, Juan F. PhD, Javier PhD, Sridharan PhD, Luiz MD, Wayne PhD,