Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8679819 | Trends in Cardiovascular Medicine | 2018 | 36 Pages |
Abstract
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (scaRNAs) are a subset of the snoRNA family and collect in the Cajal body where they perform their canonical function to biochemically modify spliceosomal RNAs prior to maturation. Failure of sno/scaRNAs have been implicated in pathology such as congenital heart anomalies, neuromuscular disorders, and various malignancies. Thus, understanding of sno/scaRNAs demonstrates the clinical value.
Keywords
R2TPCLLncRNASnoRNAssmall nucleolar RNAsDKC1MBNL1TERCVRK1NOPSmall nuclear RNAsPoly(A)-specific ribonucleaserRNAPARNribosomal RNAsTelomerase RNA componentsnRNAsNTDlncRNASAMRNPCTDTOFSMN1RVOTnoncoding RNAsmall nucleolar RNAS-adenosyl-methioninespinal muscular atrophyArgonauteright ventricular outflow tract obstructionCajal bodyAlternative splicingN-terminal domaincarboxyl-terminal domainSMAribonucleoproteinLong noncoding RNAChronic lymphocytic leukemia (CLL)Multiple myelomaMicro-RNAMiRNANucleolar proteinAGO
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Authors
Thuy BS, Sheeja MSc, MPhil, Saheli PhD, Buddhadeb MD, Douglas C. PhD, Johnson PhD,