Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8679857 | Trends in Cardiovascular Medicine | 2018 | 26 Pages |
Abstract
Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.
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Authors
Arja Suzanne MD, MSc (EBP), Sally-Ann B. MBBCh, MSc (Med), FCP (SA)Paed, PhD, Arthur A.M. MD, PhD, Nico A. MD, PhD,