| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8685616 | Journal of Neuroimmunology | 2018 | 11 Pages |
Abstract
Amelioration of signs of experimental autoimmune encephalomyelitis (EAE, a multiple sclerosis model) that is induced by intrathecal delivery of CGRP neuropeptide, is accompanied by a context-dependent decrease in expression of markers associated to opposite inflammatory activity profiles in EAE, pro-inflammatory markers (IL-1 beta and IL-6) as well as anti-inflammatory markers (Ym1/Chil3, Arg1, CD163). It is hypothesized that, by this novel mechanism, CGRP promotes down-regulation of immune cell activation that facilitates the establishment of a beneficial environment in EAE provided also by other factors.192
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Authors
Ilaria Rossetti, Laura Zambusi, Annamaria Finardi, Antonella Bodini, Luciano Provini, Roberto Furlan, Stefano Morara,