Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8685631 | Journal of Neuroimmunology | 2018 | 20 Pages |
Abstract
Adipokines secreted by fatty tissue have inflammatory properties and are suggested biomarkers of MS disease activity. To assess this, 88 MS patients were followed with nine repeated measurements of leptin and adiponectin and 12 magnetic resonance imaging (MRI) scans for two years; six months without any immunomodulatory treatment followed by 18â¯months during interferon-beta (IFNB) treatment. Serum levels of leptin dropped and adiponectin increased upon initiation of IFNB-therapy, but were not associated with clinical or MRI disease activity or with treatment response. Our findings indicate that leptin and adiponectin are not useful as biomarkers of MS disease activity.
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Authors
Silje Stokke Kvistad, Kjell-Morten Myhr, Trygve Holmøy, JÅ«ratÄ Å altytÄ Benth, Stig Wergeland, Antonie G. Beiske, Kristian S. Bjerve, Harald Hovdal, Rune Midgard, Jørn V. Sagen, Ãivind Torkildsen,