Unbalanced plasma TNF-α and IL-12/IL-10 profile in women with migraine is associated with psychological and physiological outcomes

Schematic representation of possible participation of the reciprocal, negative regulation between TNF-α and IL-12p70/IL1-0 in the pathogenesis of migraines and its major psychiatric comorbidity anxiety, and functional capacity (cardiorespiratory fitness). These cytokines might partly explain head pain itself, and common mood/anxiety-related premonitory (prodromic) symptoms (TNF-α-and IL-12p70-mediated), as well the self-limiting feature (IL-10-mediated) of migraine attacks.67