Localized AL amyloidosis of the tongue: A case report and literature review

In English literature, 25% of patients with systemic amyloidosis show macroglossia related to tongue amyloidosis, and there was no consensus for management of localized tongue amyloidosis. Some reports indicated there was no case of localized amyloidosis progressing to the systemic form. On the other hand, there were some reports that amyloidosis of mucosal sites in the head and neck was associated with underlying malignancy. Careful regular follow-up for this disease is thus necessary. Because therapeutic principles are different between localized tongue amyloidosis and oral amyloidosis related to systemic form, oral surgeons must investigate systemic involvement in cases like this.