| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8718588 | Injury | 2018 | 8 Pages |
Abstract
In our study, EGF promoted locomotor recovery and motor neuron survival of SCI rats. EGF treatment significantly decreased Bax and increased Bcl-2 protein expressions both in spinal cord and brain when compared to SCI group. Moreover, antioxidant enzyme activities including catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were increased following EGF treatment similar to MP treatment. Our experiment also suggests that alteration of the ratio of Bcl-2 to Bax may result from decreased apoptosis following EGF treatment. As a conclusion, these results show, for the first time, that administration of EGF exerts its protection via regulating apoptotic and oxidative pathways in response to spinal cord injury in different regions of central nervous system.
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Authors
Anil Murat Ozturk, Murat Celal Sozbilen, Elvin Sevgili, Taner Dagci, Halit Ãzyalcin, Guliz Armagan,