| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8727391 | Gastroenterology | 2017 | 55 Pages |
Abstract
In HIS-HUHEP mice, HBV infection completes a full life cycle and recapitulates some of the immunopathology observed in patients with chronic infection. Inoculation with different viral loads led to different immune responses and levels of virus control. We found HBV to infect liver progenitor cells, which could be involved in hepatocellular carcinogenesis. This is an important new system to study anti-HBV immune responses and screen for combination therapies against hepatotropic viruses.
Keywords
HBcAgHBsAgHBEHBSIL10TLRCHBETVLPCcccDNAhepatitis B surfaceCXCL10Human immune systemPD-L1Nucleos(t)ide analogWPIPD-1qPCRTNFPD-1 ligandnatural killercovalently closed circular DNAHCChuman albuminHepatitis B surface antigenEntecavirinterferonIFNELISAEnzyme-linked immunosorbent assayToll-like receptorHISNK cellliver progenitor celltumor necrosis factorTRAILMouse modelProgrammed death-1Human hepatocyteshepatitis B core antigenHBVquantitative polymerase chain reactionhepatitis B virusHepatocellular carcinomanuc
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Authors
Mathilde Dusséaux, Guillemette Masse-Ranson, Sylvie Darche, James Ahodantin, Yan Li, Oriane Fiquet, Elodie Beaumont, Pierrick Moreau, Lise Rivière, Christine Neuveut, Patrick Soussan, Philippe Roingeard, Dina Kremsdorf, James P. Di Santo,