Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8744512 | Anaerobe | 2018 | 17 Pages |
Abstract
The in vitro activity of DS-2969b, a novel GyrB inhibitor, and six comparator agents was studied against 101 recent North American Clostridioides difficile isolates, 46 other intestinal anaerobes and 51 strains of methicillin-resistant Staphylococcus aureus. The MIC ranges (MIC90s) of DS-2969b against C. difficile and S. aureus were 0.03-0.125 (0.125) μg/ml and 0.125-1 (0.5) μg/ml, respectively. DS-2969b showed the greatest activity of the agents tested. There was no difference in MICs of DS-2969b among different ribotypes.
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Authors
K.L. Tyrrell, D.M. Citron, C.V. Merriam, E. Leoncio, E.J.C. Goldstein,