Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8745041 | Current Opinion in Microbiology | 2018 | 10 Pages |
Abstract
Systematic experimental approaches have led to construction of comprehensive genetic and protein-protein interaction networks for the budding yeast, Saccharomyces cerevisiae. Genetic interactions capture functional relationships between genes using phenotypic readouts, while protein-protein interactions identify physical connections between gene products. These complementary, and largely non-overlapping, networks provide a global view of the functional architecture of a cell, revealing general organizing principles, many of which appear to be evolutionarily conserved. Here, we focus on insights derived from the integration of large-scale genetic and protein-protein interaction networks, highlighting principles that apply to both unicellular and more complex systems, including human cells. Network integration reveals fundamental connections involving key functional modules of eukaryotic cells, defining a core network of cellular function, which could be elaborated to explore cell-type specificity in metazoans.
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Authors
Benjamin VanderSluis, Michael Costanzo, Maximilian Billmann, Henry N. Ward, Chad L. Myers, Brenda J. Andrews, Charles Boone,