| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8749545 | Microbial Pathogenesis | 2018 | 8 Pages |
Abstract
Most enveloped viruses exploit complex cellular pathways for assembly and egress from the host cell, and the large DNA virus Herpes simplex virus 1 (HSV-1) makes no exception, hijacking several cellular transport pathways for its glycoprotein trafficking and maturation, as well as for viral morphogenesis and egress according to the envelopment, de-envelopment and re-envelopment model. Importantly Rab GTPases, widely distributed master regulators of intracellular membrane trafficking pathways, have recently being tightly implicated in such process. Indeed, siRNA-mediated genetic ablation of specific Rab proteins differently affected HSV-1 production, suggesting a complex role of different Rab proteins in HSV-1 life cycle. In this review, we discuss how different Rabs can regulate HSV-1 assembly/egress and the potential therapeutic applications of such findings for the management of HSV-1 infections.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
Sohail Raza, Gualtiero Alvisi, Farzana Shahin, Urooj Husain, Masood Rabbani, Tahir Yaqub, Aftab Ahmad Anjum, Ali Ahmad Sheikh, Muhammad Nawaz, Muhammad Asad Ali,