Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8750329 | New Microbes and New Infections | 2017 | 15 Pages |
Abstract
Enterobacteriaceae with blaNDM-7 is only infrequently observed. Self-transmissible plasmids carrying the blaNDM gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a blaNDM-7-positive Escherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as E. coli ST-167 with IncX3 plasmid carrying blaNDM-7 in addition to blaTEM-1 and blaCMY-42 genes. The identification of IncX3-blaNDM-7 combination is the first report in India where blaNDM-7 is known to cause higher resistance to carbapenems compared to its variants.
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Authors
N.K. Devanga Ragupathi, D.P. Muthuirulandi Sethuvel, R. Gajendiran, J.L.K. Daniel, K. Walia, B. Veeraraghavan,