Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8750722 | Respiratory Investigation | 2018 | 4 Pages |
Abstract
A 70-year-old Japanese man with recurrent squamous cell carcinoma of the head and neck presented with severe interstitial pneumonia associated with nivolumab, after talc slurry pleurodesis. Following the development of malignant pleural effusion, he underwent chest drainage and was administered intrathoracic talc as a pleurodesis. Two weeks later, we administered nivolumab (3Â mg/kg) to be repeated every 2 weeks. However, on day 12, chest computed tomography scan demonstrated diffuse non-segmental ground-glass opacity and mild bronchiectasis. We diagnosed interstitial pneumonia associated with nivolumab. Although corticosteroid pulse therapy was initiated, the patient died of respiratory failure on day 14.
Keywords
AIPNivolumabSqCCPleurodesisIRAEARDSOK-432SP-DCOPKL-6Surfactant protein-DGGOcomputed tomographyforced expiratory volume in one secondKrebs von den Lungen-6Acute respiratory distress syndromeAnti-PD-1talcVital capacityimmune-related adverse eventlactate dehydrogenaseLDHEastern Cooperative Oncology Group Performance StatusC-reactive proteinCRPacute interstitial pneumoniaInterstitial pneumoniaCryptogenic organizing pneumoniaSquamous cell carcinomaground-glass opacity
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Authors
Shinya Sakata, Yuichiro Matsuoka, Kenta Kawahara, Yosuke Kakiuchi, Akira Takaki, Akiyuki Hirosue, Ryoji Yoshida, Sho Saeki, Kazuhiko Fujii, Hideki Nakayama,