Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8791862 | Experimental Eye Research | 2018 | 31 Pages |
Abstract
The levels of the studied factors changed throughout the dynamic course of the ocular injury. The prolonged increased levels of limbal MCP-1 and IL-8 may contribute to the continuous recruitment of inflammatory cells, characterizing the symptoms of the late pathology. The significantly elevated IL-1β and IL-6 at 1w, after the resolution of the acute injury but before the clinical manifestation of the late pathology suggests a therapeutic window for intervention with prevention therapy. Mapping the expression pattern of these cytokines and chemokines points out towards stage-specific therapeutic options.
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Authors
Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Hillel Buch, Tamar Kadar, Ariel Gore,