Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8791969 | Experimental Eye Research | 2018 | 27 Pages |
Abstract
The IOP averages during three weeks were 22.35â¯Â±â¯1.23â¯mmHg (meanâ¯Â±â¯SD), 20.91â¯Â±â¯1.97â¯mmHg, and 9.67â¯Â±â¯0.42â¯mmHg, with 50.2%, 44.00% and 66.76% RGC loss by 8 weeks, respectively, in the microbead group, EVC group and NMDA group. Decreased thickness in the GCL was observed in all three groups, while the thickness of IRL and ONL was decreased in the EVC and NMDA groups. Significant positive correlation of RGC loss rate with ÎIOP integral were demonstrated in both microbead and EVC models. Moreover, we found that the PhNR amplitudes declined early by the first day in the NMDA group, 5 days later in the EVC group and by 7 days in the microbead group. Each glaucomatous rat model has its strength and weakness. Our study provides detailed data for choosing suitable animal models to advance glaucoma research.
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Authors
Wanjing Huang, Fangyuan Hu, Min Wang, Fengjuan Gao, Ping Xu, Chao Xing, Xinghuai Sun, Shenghai Zhang, Jihong Wu,