Riding the cell jamming boundary: Geometry, topology, and phase of human corneal endothelium

This study showed the corneal endothelium acts as a glassy viscous foam characterized by well-established physical laws. Endothelial cell death transiently and locally increases cell fluidity, which is subsequently arrested by jamming of the pleomorphically diverse cell collective, via rearrangement and shape change of a small proportion of cells, which become locked in place by their neighbours thereby maintaining structural equilibrium with little energy expenditure.