Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8842164 | Progress in Neurobiology | 2018 | 68 Pages |
Abstract
Age related neurodegenerative disorders (ARND) are presented as the most debilitating and challenging diseases associated with the central nervous system. Despite the advent of active molecules with a positive role on neurodegenerative mechanisms, many of the current therapeutic strategies remain ineffective in treating or preventing ARND. Lipid nanocarriers have emerged as efficient delivery systems with the capability to cross biological barriers, especially the blood brain barrier (BBB). Also, when associated to natural compounds, lipid nanocarriers have demonstrated to be an interesting alternative to ARND therapies with multiple beneficial effects. This comprehensive review focus on state-of-the-art lipid based nanocarriers for the delivery of natural compounds targeting neurodegeneration. A critical analysis of published reports will be also provided giving indications to researchers about the most promising ARND nanotherapy strategies.
Keywords
TBISLNNLCLDLRRNSAPPEGCGAMTRMTNFTCMTTransferrinTFRCPPARNDmAbLEPRLEPSDSCOXCIRPS80LFRDMSONFκBROSTraumatic brain injurySpinal cord injuryMonoclonal antibodycyclooxygenaseAChAChEAcetylcholineamyotrophic lateral sclerosisNeuroinflammationepigallocatechin gallatecerebral ischemia/reperfusionAlzheimer diseaseALSHuntington diseaseParkinson diseaseNatural compoundstumor necrosis factor αNanostructured lipid carriersCarrier-mediated transportTriggeringblood brain barrierBBBsenile plaquessciTNF-αnuclear factor κBLactoferrinLeptinLow-density lipoproteinLDLMannoseManMultiple sclerosisNanocarriersSolid lipid nanoparticlesLipid nanocarriersTargetingamyloid precursor proteinPolysorbate 80PEGCell penetrating peptidesCholinesterasereactive nitrogen speciesReactive oxygen speciestransferrin receptorLactoferrin ReceptorLeptin receptor
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Authors
Telma Bezerra Soares, LuÃs Loureiro, Ana Carvalho, Maria Elisabete C.D. Real Oliveira, Alberto Dias, Bruno Sarmento, Marlene Lúcio,