Genetic polymorphisms related to behavioral approach and behavioral inhibition scales

•This study provides one of the first polygenic examinations of BIS and BAS scores.•BDNF was significantly related to threat sensitivity.•OPRM1 was related to reward sensitivity in interaction with early adversity.•The findings support the merit of combined psychological and genetic approach.•Findings provide further evidence for the validity of the BIS/BAS scales.

Genetic polymorphisms relevant to behavioral approach and behavioral inhibition are examined, using a polygenic approach while also considering the role of early adversity. Undergraduates (N = 343) completed the well-validated Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales and provided blood for genotyping. The BDNF met allele was related to higher BIS scores. OPRM1 status interacted with a measure of early adversity to predict the BAS Reward Responsiveness subscale. Results provide additional support for the validity of the BIS/BAS scales, and suggest combined genetic and environmental influences on the development of these traits.

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