Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8918036 | Current Opinion in Systems Biology | 2018 | 10 Pages |
Abstract
As our catalog of cell states expands, appropriate characterization of these states and the transitions between them is crucial. Here we discuss the roles of intermediate cell states (ICSs) in this growing collection. We begin with definitions and discuss evidence for the existence of ICSs and their relevance in various tissues. We then provide a list of possible functions for ICSs with examples. Finally, we describe means by which ICSs and their functional roles can be identified from single-cell data or predicted from models.
Keywords
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Physical Sciences and Engineering
Computer Science
Computer Science (General)
Authors
Adam L. MacLean, Tian Hong, Qing Nie,