Quantitative proteomics of model organisms

Surveying of entire proteomes is primarily enabled by mass spectrometry-based proteomics technologies. Advances in the last decade have significantly reduced the effort involved in global or targeted quantitative proteome analyses and have facilitated the collection of increasingly more comprehensive proteomics data for different species. Here we review how mass spectrometry-based tools enable mapping and quantitative profiling of proteomes and post-translational modifications from various model organisms. Further, we discuss recent proteomic approaches that enable exploration of the topological organization, dynamic turnover, structural features, and other properties of model organism proteomes beyond protein expression profiles.