Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8920151 | Cell Regeneration | 2014 | 7 Pages |
Abstract
Polyoxometalates are highly potent, nanomolar range inhibitors of the DNA binding activity of the Sox-HMG family. However, binding assays involving a limited subset of structurally diverse polyoxometalates revealed a low selectivity profile against different transcription factor families. Further progress in achieving selectivity and deciphering structure-activity relationship of POMs require the identification of POM binding sites on transcription factors using elaborate approaches like X-ray crystallography and multidimensional NMR. In summary, our report reaffirms that transcription factors are challenging molecular architectures and that future polyoxometalate chemistry must consider further modification strategies, to address the substantial challenges involved in achieving target selectivity.
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Authors
Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf, Ralf Jauch,